Paediatric journal article watch

Journal Watch (Spring 2017)

Journal Watch Non-HLA antibodies

The clinical impact of non-HLA specific antibodies either alone or in concert with donor HLA specific antibodies (DSA) has been an intense area of research in kidney transplantation and more recently in thoracic transplantation as well. These non-HLA antigens include receptors expressed by the vascular endothelium such as the G protein coupled receptors (GPCRs), Major Histocompatibility Complex...

Journal Article

Four lines of evidence support a central role for H. pylori and PUD: (1) the natural history of H. pylori infection, (2) epidemiologic data, (3) outcomes after cure of H. pylori infection in patients with PUD, and (4) the frequent development of gastric ulcers in H. pylori-infected Mongolian gerbils. With so much circumstantial evidence and with Koch's postulates arguably fulfilled for a direct...

Journal Article

Journal Article

It is now recognized that there is a two-way interaction between Helicobacter pylori gastritis and gastric physiology. H. pylori gastritis can alter gastric physiology, leading to increased or decreased acid secretion depending on the pattern of gastritis present. These changes in physiology are related to the disease outcome, with increased acid secretion leading to duodenal ulcer disease and ...